The symptoms of porphyria are many and varied. Each porphyria patients reacts differently from another. Also many medical professionals including physicians are still learning about porphyria and many may never have treated a patient with porphyria. The following symptomology is classifed according to types.

General

Abdominal pain Abdominal tenderness Loss of appetite Nausea Vomiting Constipation Carbohydrate craving Breast secretions Diarrhea Partial ileus [Intestinal blockage] Abdominal distention Dysuria Painful Urination Bladder Dysfunction Urinary Retention Amenorrhea Lack of menses

Physical Findings of Acute Attack

Red or dark urine Tachycardia Pulse 100 Labile hypertension 90 diastolic Fever [Pyrexia] Profused sweating Edema Postural Hypotension [Low Blood Pressure] Hypertrichosis [excessive body hair growth] Hyperpigmentation [skin coloring]

Neurological Symptoms of Acute Attack Peripheral manifestations

Peripheral neuropathy Muscle weakness Paresis . paralysis Sensory disorde Respiratory paralysis Foot drop Wrist drop Abnormal Gait Pain Arms, legs, hips and/or lower back Loss of sensation Dyesthesia Numbness Tingling Burning Sensation Bulbar paresis Tongue paralization Mouth paralization Throat paralization

Cerebral manifestations

Behavorial change Anxiety Irritability Delirium Depression Confusion Hallucination Insomnia ANS altered neurological state Restlessness Sensory loss Seizure Depressed or absent tendon reflexes Cranial nerve involvement

Hematology Blood Chemistry

Hyponatremia Below normal sodium level Increased Bun Urea Nitrogen Increased AST Aspartate Aminotransferase Elevated Alkaline Phosphatase Liver panel test Increased ALT Aspartate Aminotransferase Hypokalemia Below normal potassium level Leukocytosis Abnormal increase in WBC 10,000 Increased ESR Hypochloremia Anemia

Cutaneous manifestations

Skin photosensitivity Blistering Severe Tissue Scarring Increased Hair growth Pigmentation Darkening Thickening of skin Severe Itching

Special lab studies

Decreased blood volume EEG abnormalities Electromyographic abnormalities Muscle denervation Decreased nerve conduction velocity Abnormal CSF Increased fibrillation potential